Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
نویسندگان
چکیده
منابع مشابه
Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimer's Disease
Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite 30+ years of intense investigation, the field lacks consensus regarding the etiology and pathogenesis of sporadic AD, and therefore we still do not know the best strategies for treating and preventing this debilitating and costly disease. However, growing evidence supports the concept that AD is fundamentall...
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Growing evidence supports roles for brain insulin and insulin-like growth factor (IGF) resistance and metabolic dysfunction in the pathogenesis of Alzheimer's disease (AD). Whether the underlying problem stems from a primary disorder of central nervous system (CNS) neurons and glia, or secondary effects of systemic diseases such as obesity, Type 2 diabetes, or metabolic syndrome, the end-result...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2012
ISSN: 1567-2050
DOI: 10.2174/156720512799015037